Immune synapses formed by T and NK cells both show segregation of the integrin ICAM1 from other proteins such as CD2 (T cell) or KIR (NK cell).However, the mechanism by which these proteins segregate remains unclear; one key hypothesis is a redistribution based on protein size.Simulations of this mechanism qualitatively reproduce observed segregati
Delivery of therapeutic transgenes with adeno-associated viral (AAV) vectors for treatment of myopathies has yielded encouraging results in animal models and early clinical studies.Although certain AAV serotypes efficiently target muscle fibers, transduction of the muscle stem cells, also known as satellite cells, is less studied.Here, we used a Pa
Acinetobacter baumannii is a multidrug-resistant nosocomial opportunistic pathogen that is becoming a major health threat worldwide.In this study, we have focused on the A.baumannii DSM30011 strain, an environmental isolate that retains many virulence-associated traits.We found that its genome contains two loci encoding for contact-dependent growth
Abstract Background Increases in global mean temperature, changes in rainfall patterns, and extreme climatic events are expected results of climate change.The individual effects of elevated temperature and precipitation on insect pests due to the impact of climate change have been widely modeled individually but their combined effects are poorly un
Michelle ngetikin Y Peng,1 Stephen Hannan,2 David Teenan,2 Steven J Schallhorn,1,3 Julie M Schallhorn1,4 1Department of Ophthalmology, University of California, San Francisco, CA, USA; 2Optical Express, Glasgow, UK; 3Carl Zeiss Meditec, CA, USA; 4F.I.Proctor Foundation, University of California, San Francisco, CA, USA Background: To evaluate the ef